Pyridine → HCID 20165436, 화합물

HRID 256098노트

반응식

HRID 256098 반응식
[CH3:1][CH:2]1[CH:9]2[CH2:10][CH:5]([C:6]([CH3:11])=[CH:7][CH2:8]2)[CH:4]([OH:12])[CH2:3]1.[C:13](OC(=O)C)(=[O:15])[CH3:14].N1C=CC=CC=1>O1CCCC1>[C:13]([O:12][CH:4]1[CH2:3][CH:2]([CH3:1])[CH:9]2[CH2:10][CH:5]1[C:6]([CH3:11])=[CH:7][CH2:8]2)(=[O:15])[CH3:14]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 20165425HCID 20165425, 화합물

생성물 1

HCID 20165436HCID 20165436, 화합물수율 87%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 10 g (60.2 mmol) of 4,8-dimethylbicyclo[3.3.1]nona-7-en-2-ol [IA] in 40 ml of tetrahydrofuran were added 6.8 g (66.6 mmol) of acetic anhydride and 5.2 g (65.7 mmol) of pyridine and the resulting mixture was heated under reflux for 5 hours. After cooling, the tetrahydrofuran was distilled off, the residue was subjected to column chromatography and eluate with toluene gave 10.9 g of the title compound, which had a woody-like smell.

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling
  4. distillationthe tetrahydrofuran was distilled off

출처 및 근거

ORD 기록
ord-21a8455de4b441a6a36b02930fafc00f
출처 데이터셋
uspto-grants-1987_10
특허 번호
US04700008

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