(2,3,5-Trifluoropyridin-4-yl)methanol → HCID 86741836, compound

HRID 256161Notes

Reaction equation

HRID 256161 reaction equation
[OH:1][CH2:2][C:3]1[C:8]([F:9])=[CH:7][N:6]=[C:5]([F:10])[C:4]=1[F:11].[Cl:12][C:13]([C:23]([F:26])([F:25])[F:24])=[CH:14][C@@H:15]1[C@H:17]([C:18](Cl)=[O:19])[C:16]1([CH3:22])[CH3:21]>>[Cl:12][C:13]([C:23]([F:24])([F:25])[F:26])=[CH:14][C@@H:15]1[C@H:17]([C:18]([O:1][CH2:2][C:3]2[C:8]([F:9])=[CH:7][N:6]=[C:5]([F:10])[C:4]=2[F:11])=[O:19])[C:16]1([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 13985162(2,3,5-Trifluoropyridin-4-yl)methanolHCID 86737382cis-3-(2-Chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarbonyl chloride

Product 1

HCID 86741836HCID 86741836, compoundYield 45.1%

Procedure

By the method of Example 2, 0.3 g (0.002 mole) of 4-hydroxymethyl-2,3,5-trifluoropyridine (from Example 9) was reacted with 0.5 g (0.002 mole) of cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarbonyl chloride to produce 0.35 g of (2,3,5-trifluoropyridin-4-yl)methyl cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate as a clear, yellow oil, Compound 15 of the tables below.

Sources & evidence

ORD record
ord-1172845dfea74231973f73aa88cc26bc
Source dataset
uspto-grants-1987_10
Patent number
US04701464

Reaction notes

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