2-(Bromomethyl)-6-fluoropyridine → 2-Bromoethyl-6-fluoropyridine

HRID 256170Notes

Reaction equation

HRID 256170 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[N:4]=1.[Br:10][CH:11](Br)C1C=CC=C(F)N=1>>[Br:10][CH2:11][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[N:4]=1

Participants

3

Reactant 2

HCID 139852182-(Bromomethyl)-6-fluoropyridine2×HCID 201642372-(Dibromomethyl)-6-fluoropyridine

Product 1

HCID 201642322-Bromoethyl-6-fluoropyridine

Procedure

Fractions 2 and 3 were >96% pure 2-bromomethyl-6-fluoropyridine and were therefore combined. Fraction 4 was composed of a 1:1 mixture of 2-bromomethyl-6-fluoropyridine and 2-dibromomethyl-6-fluoropyridine. The nmr spectra was consistent with the proposed structure for Fractions 2 and 3.

Sources & evidence

ORD record
ord-8768866ccc434663906aa8f5a0dc546b
Source dataset
uspto-grants-1987_10
Patent number
US04701464

Reaction notes

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