Bromomethylcyclopropane → HCID 178420903, compound

HRID 256281Notes

Reaction equation

HRID 256281 reaction equation
[SH:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.C[O-].[Na+].[CH:10]1([CH2:13]Br)[CH2:12][CH2:11]1>CO>[CH:10]1([CH2:13][S:1][C:2]2[N:6]=[CH:5][NH:4][N:3]=2)[CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 81503BromomethylcyclopropaneHCID 10942334Sodium MethoxideHCID 178527894HCID 178527894, compound

Product 1

HCID 178420903HCID 178420903, compoundYield 99.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3-mercapto-1,2,4-triazole (7.1 g) and sodium methoxide (3.8 g) in methanol (100 ml), there was added cyclopropylmethyl bromide (9.5 g), and the resultant mixture was allowed to stand at room temperature for 10 hours. After removal of the solvent, the residue was extracted with chloroform. Evaporation of the chloroform extract gave 10.8 g of 3-cyclopropylmethylthio-1,2,4-triazole. Yield, 99%. M.P., 69°-70° C.

Workup

  1. customAfter removal of the solvent
  2. extractionthe residue was extracted with chloroform
  3. customEvaporation of the chloroform
  4. extractionextract

Sources & evidence

ORD record
ord-5ff60d7a4e704f758b67bc2c184e22e6
Source dataset
uspto-grants-1987_10
Patent number
US04702764

Reaction notes

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