反应详情

温度

5 °C

104 g of triethylamine and 890 cc of chloroform were introduced into a 3 liter balloon flask provided with a sealed agitator, a reflux condenser and a thermometer. The solution obtained was cooled to 5° C. 51 g of amino acetonitrile hydrochloride was then gradually added, with the temperature being maintained at between 5° and 10° C. Thereafter over a period of 30 minutes and at a temperature of between 0° and 5° C., 143 g of 2-acetoxy 4-acetamino 5-chlorobenzoyl chloride in finely divided form was added. A dark-coloured solution resulted, which was agitated, first, for a period of 2 hours at 10° C. and, thereafter, for 2 hours at ambient temperature.

1. customprovided with a sealed agitator, a reflux condenser
2. customThe solution obtained
3. temperaturebeing maintained at between 5° and 10° C
4. customA dark-coloured solution resulted
5. waitfirst, for a period of 2 hours at 10° C.
6. waitfor 2 hours at ambient temperature