HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 256353Generated: October 26, 2026
Dicyclohexylcarbodiimide → 1-[2-(Benzyloxycarbonylamino)acetyl]-2,2-dimethyl-4-imidazolidinone
https://huagongshe.com/reaction/256353
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | 2,2-Dimethylimidazolidin-4-one | HCID 21279295 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[2-(Benzyloxycarbonylamino)acetyl]-2,2-dimethyl-4-imidazolidinone | HCID 20163731 | — |
Reaction Steps
To an ice-cold solution of N-(benzyloxycarbonyl) glycine (9 g) and 2,2-dimethyl-4-imidazolidinone (5 g) in tetrahydrofuran (THF) (150 ml) a solution of dicyclohexylcarbodiimide (DCC) (9 g) in THF (50 ml) was added dropwise. After stirring for 3 hours at 20° C., the precipitate was filtered off, the filtrate was evaporated to dryness and the residue was crystallized from 2-propanol affording 12 g of the title compound, m.p. 135°-136° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04703054 |
|---|
| Source dataset | uspto-grants-1987_10 |
|---|
| ORD ID | ord-cc6c00ac38d44d00a5d397f316c069a1 |
|---|
| Source note | uspto-grants-1987_10 |
|---|
