反应详情

温度

20 °C

To an ice-cold solution of N-(benzyloxycarbonyl) glycine (9 g) and 2,2-dimethyl-4-imidazolidinone (5 g) in tetrahydrofuran (THF) (150 ml) a solution of dicyclohexylcarbodiimide (DCC) (9 g) in THF (50 ml) was added dropwise. After stirring for 3 hours at 20° C., the precipitate was filtered off, the filtrate was evaporated to dryness and the residue was crystallized from 2-propanol affording 12 g of the title compound, m.p. 135°-136° C.

1. filtrationthe precipitate was filtered off
2. customthe filtrate was evaporated to dryness
3. customthe residue was crystallized from 2-propanol affording 12 g of the title compound, m.p. 135°-136° C.