Acetic Anhydride → 1-(2-Acetamidoacetyl)-2,2-dimethyl-4-imidazolidinone

HRID 256371Notes

Reaction equation

HRID 256371 reaction equation
[NH2:1][CH2:2][C:3]([N:5]1[CH2:9][C:8](=[O:10])[NH:7][C:6]1([CH3:12])[CH3:11])=[O:4].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([NH:1][CH2:2][C:3]([N:5]1[CH2:9][C:8](=[O:10])[NH:7][C:6]1([CH3:12])[CH3:11])=[O:4])(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 201637131-(2-Aminoacetyl)-2,2-dimethyl-4-imidazolidinone

Product 1

HCID 201637081-(2-Acetamidoacetyl)-2,2-dimethyl-4-imidazolidinone

Procedure

A suspension of 1-(2-aminoacetyl)-2.2-dimethyl-4-imidazolidinone (5 g) in acetic anhydride (20 ml) was stirred at room temperature for 1 hour. Evaporation under vacuum and crystallization of the residue from 2-propanol gave 4.63 g of the title compound, m.p. 214°-215° C.

Workup

  1. customEvaporation
  2. customunder vacuum and crystallization of the residue from 2-propanol

Sources & evidence

ORD record
ord-9e503bd0e6b64536b7061cc7c8bfff86
Source dataset
uspto-grants-1987_10
Patent number
US04703054

Reaction notes

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