Sodium borohydride → HCID 15595611, compound

HRID 256382Notes

Reaction equation

HRID 256382 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[S:11][CH2:10][CH2:9][C:8]2=[O:13].[BH4-].[Na+]>CO.O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[S:11][CH2:10][CH2:9][CH:8]2[OH:13]

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 64553542,3-Dihydro-8-methoxy-4H-1-benzothiopyran-4-one

Product 1

HCID 15595611HCID 15595611, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

89 mmol of 8-methoxy-4-thiochromanone are dissolved in 70 ml of a mixture of methanol and tetrahydrofuran (3/4). 134 mmol of sodium borohydride dissolved in 50 ml of aqueous methanol (50%) are added. After stirring for 1 hour at room temperature and then extracting with methylene chloride, the resulting product is recrystallised from a mixture of methanol and diethyl ether (1/10).

Workup

  1. additionare added
  2. extractionextracting with methylene chloride
  3. customthe resulting product is recrystallised from a mixture of methanol and diethyl ether (1/10)

Sources & evidence

ORD record
ord-4fc7ab4f2da34affa9b199ec66ff5b1a
Source dataset
uspto-grants-1987_10
Patent number
US04703057

Reaction notes

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