反应详情

Reduction of 444 mg (2 mmole) ethyl 2-hydroxymethyl-2,3-dihydrobenzofuran-5-carboxylate, Preparation A, Part (iii), in 15 ml tetrahydrofuran with lithium aluminum hydride, 155 mg (4 mmole), by the method of Preparation A, Part iv), afforded 0.3 g of 2,5-bis-hydroxymethyl-2,3-dihydrobenzofuran as an oil, TLC 1:2 ethyl acetate/hexane, Rf 0.2, iodine positive. 1H-NMR(CDCl3)ppm(delta): 3.6 (CH2OH at 2-position), 4.6 (CH2OH at 5-position).