Water → Ethyl 2-(2-formamido-5-chlorothiazol-4-yl)-2-methoxyiminoacetate

HRID 256426Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 256426
[Cl:1]N1C(=O)N(Cl)C(=O)N(Cl)C1=O.[CH:13]([NH:15][C:16]1[S:17][CH:18]=[C:19]([C:21](=[N:27][O:28][CH3:29])[C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:20]=1)=[O:14].O>CN(C)C=O>[CH:13]([NH:15][C:16]1[S:17][C:18]([Cl:1])=[C:19]([C:21](=[N:27][O:28][CH3:29])[C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:20]=1)=[O:14]

Komponenten

5

Edukt 3

HCID 962WaterHCID 6909Trichloroisocyanuric AcidHCID 53737196Ethyl 2-(2-formamidothiazol-4-yl)-2-methoxyiminoacetate

Produkt 1

HCID 54156297Ethyl 2-(2-formamido-5-chlorothiazol-4-yl)-2-methoxyiminoacetateAusbeute 224,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Trichloroisocyanuric acid (6.7 g.) was added portionwise to a chilled solution of ethyl 2-(2-formamidothiazol-4-yl)-2-methoxyiminoacetate (syn isomer, 20.0 g.) in dry dimethylformamide (400 ml.) and stirred at room temperature for 2 hrs. The reaction mixture was poured into chilled water (2 l.), and the precipitates were collected by filtration, washed with water and dried to give ethyl 2-(2-formamido-5-chlorothiazol-4-yl)-2-methoxyiminoacetate (syn isomer, 18.9 g.).

Aufarbeitung

  1. additionThe reaction mixture was poured
  2. filtrationthe precipitates were collected by filtration
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-265446d5f15d42b793fce5602b5c7b72
Quelldatensatz
uspto-grants-1987_10
Patentnummer
US04703046

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