Hydrochloric Acid → HCID 131715339, compound

HRID 256433Notes

Reaction equation

C(NC1SC(Br)=C(C(=NOC)C(N[CH:13]2[C:30](=[O:31])[N:15]3[C:16]([C:27]([OH:29])=[O:28])=[C:17]([CH2:20][S:21][C:22]4[S:23][CH:24]=[N:25][N:26]=4)[CH2:18][S:19][C@H:14]23)=O)N=1)=O.[ClH:36]>>[ClH:36].[S:23]1[CH:24]=[N:25][N:26]=[C:22]1[S:21][CH2:20][C:17]1[CH2:18][S:19][C@@H:14]2[CH2:13][C:30](=[O:31])[N:15]2[C:16]=1[C:27]([OH:29])=[O:28]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 1317153387-[2-(2-Formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetamido]-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid

Product 1

HCID 131715339HCID 131715339, compound

Procedure

7-[2-(2-Formamido-5-bromothiazol-4-yl)-2-methoxyiminoacetamido]-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid (syn isomer, 1.2 g.) was treated with conc. hydrochloric acid (2 ml.) in a similar manner to that of Example 1-(2) to give 7-[2-2-amino-5-bromothiazol-4-yl)-2-methoxyiminoacetamido]-3-(1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid hydrochloride (syn isomer, 1.2 g.).

Sources & evidence

ORD record: ord-4e8cb5a395c7478ba91c6bd0d905994e
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04703046

Reaction notes

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