2,5-Difluoro-4-chloropyrimidine → HCID 178517766, compound

HRID 256469Notes

Reaction equation

HRID 256469 reaction equation
[F:1][C:2]1[C:3](N)=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.FC1N=C([Cl:17])C(F)=CN=1>O>[OH:8][C:5]1[N:4]=[C:3]([Cl:17])[C:2]([F:1])=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 137111632,5-Difluoro-4-chloropyrimidineHCID 178509021HCID 178509021, compound

Product 1

HCID 178517766HCID 178517766, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A process has now been found for the preparation of 5-fluorocytosine, which is characterised in that 2,5-difluoro-4-chloropyrimidine is reacted with a proton acid in the presence of water to give 2-hydroxy-4-chloro-5-fluoropyrimidine, and this is reacted with ammonia to give 2-hydroxy-4-amino-5-fluoropyrimidine (=5-fluorocytosine).

Sources & evidence

ORD record
ord-26a951bfd611467bb4a600504ff48221
Source dataset
uspto-grants-1987_10
Patent number
US04703121

Reaction notes

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