反应详情

A process has now been found for the preparation of 5-fluorocytosine, which is characterised in that 2,5-difluoro-4-chloropyrimidine is reacted with a proton acid in the presence of water to give 2-hydroxy-4-chloro-5-fluoropyrimidine, and this is reacted with ammonia to give 2-hydroxy-4-amino-5-fluoropyrimidine (=5-fluorocytosine).