HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Difluoro-4-chloropyrimidine → HCID 178517766, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Difluoro-4-chloropyrimidine | HCID 13711163 | — |
| Reactant | HCID 178509021 | HCID 178509021 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178517766 | HCID 178517766 | — |
Reaction Steps
A process has now been found for the preparation of 5-fluorocytosine, which is characterised in that 2,5-difluoro-4-chloropyrimidine is reacted with a proton acid in the presence of water to give 2-hydroxy-4-chloro-5-fluoropyrimidine, and this is reacted with ammonia to give 2-hydroxy-4-amino-5-fluoropyrimidine (=5-fluorocytosine).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04703121 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-26a951bfd611467bb4a600504ff48221 |
| Source note | uspto-grants-1987_10 |