Ammonia → HCID 178517766, compound

15.05 g (0.1 mole) of 2,5-difluoro-4-chloropyrimidine were heated under reflux together with 30 ml of 37% strength aqueous hydrochloric acid for 2 hours. The volatile constituents were then stripped off in vacuo, the residue was taken up in 100 ml of water and this mixture was rendered weakly alkaline (pH 7.5) with 20% strength aqueous ammonia. The mixture was then again concentrated in vacuo down to 20% of the original volume. The solid obtained was filtered off with suction and dried. 13.7 g of product with a melting point of 176° to 177° C. (decomposition) were obtained, corresponding to a yield of 92.2%.

1. concentrationThe mixture was then again concentrated in vacuo down to 20% of the original volume
2. customThe solid obtained
3. filtrationwas filtered off with suction
4. customdried

ORD record

ord-14b49407b7d844ef9ba1b0b4ce078b98

Source dataset

uspto-grants-1987_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04703121