Ammonia → HCID 178509021, compound

HRID 256473Notes

Reaction equation

HRID 256473 reaction equation
[OH:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[NH3:10]>>[F:9][C:5]1[C:6]([NH2:10])=[N:7][C:2](=[O:1])[NH:3][CH:4]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178517766HCID 178517766, compound

Product 1

HCID 178509021HCID 178509021, compound

Procedure

A process for the preparation of 5-fluorocytosine comprising reacting 2,5-difluoro-4-chloropyrimidine with a proton acid in the presence of water to yield 2-hydroxy-4-chloro-5-fluoropyrimidine, and reacting the 2-hydroxy-4-chloro-5-fluoropyrimidine with ammonia to yield 5-fluorocytosine.

Sources & evidence

ORD record
ord-92d8dab964c24d0a9f9106caae59a01e
Source dataset
uspto-grants-1987_10
Patent number
US04703121

Reaction notes

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