Trifluoroacetic acid → HCID 131711082, compound

HRID 256491Notes

Reaction equation

HRID 256491 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:13]([N:15]1[CH2:22][CH2:21][CH2:20][C@H:16]1[C:17]([NH2:19])=[O:18])=[O:14])[C@@H:3]([CH3:12])[O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[C:30]([OH:36])([C:32]([F:35])([F:34])[F:33])=[O:31]>>[NH2:1][C@H:2]([C:13]([N:15]1[CH2:22][CH2:21][CH2:20][C@H:16]1[C:17]([NH2:19])=[O:18])=[O:14])[C@@H:3]([CH3:12])[O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[F:33][C:32]([C:30]([OH:36])=[O:31])([F:35])[F:34]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131711083HCID 131711083, compound

Product 1

HCID 131711082HCID 131711082, compound

Procedure

To 2.00 g of BOC-Thr(Bzl)-Pro-NH2, under cooling at -5° C., was added 6 ml of TFA and the mixture was stirred for 30 minutes, followed by concentration under reduced pressure. The residue was treated with diethyl ether and the product precipitated was collected by filtration and dried over sodium hydroxide under vacuo overnight to obtain H-Thr(Bzl)-Pro-NH2.TFA.

Workup

  1. concentrationfollowed by concentration under reduced pressure
  2. additionThe residue was treated with diethyl ether
  3. customthe product precipitated
  4. filtrationwas collected by filtration
  5. dry with materialdried over sodium hydroxide under vacuo overnight

Sources & evidence

ORD record
ord-b3a2c1c668f1402cab18d95609ce1a61
Source dataset
uspto-grants-1987_10
Patent number
US04703106

Reaction notes

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