HuagongsheHuagongshe Chemistry Print Report · For research reference only
Uridine → Ribavirin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Uridine | HCID 6029 | — |
| Reactant | Cytidine | HCID 6175 | — |
| Reactant | Adenosine | HCID 60961 | — |
| Reactant | Monobasic potassium phosphate | HCID 516951 | — |
| Reactant | Guanosine | HCID 135398635 | — |
| Reactant | HCID 178418936 | HCID 178418936 | — |
| Reactant | HCID 178513825 | HCID 178513825 | — |
| Reactant | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol | HCID 178521066 | — |
| Product | Ribavirin | HCID 37542 | — |
Reaction Steps
By using a substrate solution (pH 6.0) containing 40 mM 1, 2, 4-triazole-3-carboxamide (hereinafter called "triazole") as the base donor, 40 mM uridine, inosine, cytidine, adenosine or guanosine as the saccharide residue donor and 40 mM potassium dihydrogenphosphate, ribavirin was produced in the same manner as in Example 1. The results are shown in Table 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05258301 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-083540e260744b8b94717887f3bd53ce |
| Source note | uspto-grants-1993_11 |