反应详情

A mixture of 2-benzyloxycarbonylmethyl-2-(pyrrol-1-yl)malonic acid diethyl ester (80.0 g) in dioxane (150 ml) was hydrogenated over 10% palladium-carbon (500 mg) at 40° C. After the calculated amount of hydrogen was absorbed, the catalyst was filtered off and the filtrate was evaporated under reduced pressure. The residue was recrystallized from ethyl acetate/n-hexane to give the title compound (48.7 g, 80.2%) as colorless crystals, mp 93°-94° C.

1. customAfter the calculated amount of hydrogen was absorbed
2. filtrationthe catalyst was filtered off
3. customthe filtrate was evaporated under reduced pressure
4. customThe residue was recrystallized from ethyl acetate/n-hexane