Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Benzyloxycarbonylmethyl-2-(pyrrol-1-yl)malonic acid diethyl ester → 2-Carboxymethyl-2-(pyrrol-1-yl)-malonic acid diethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Benzyloxycarbonylmethyl-2-(pyrrol-1-yl)malonic acid diethyl ester | HCID 10619340 | — |
| 촉매 | HCID 178418390 | HCID 178418390 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-Carboxymethyl-2-(pyrrol-1-yl)-malonic acid diethyl ester | HCID 10802905 | 80.2% |
반응 단계
A mixture of 2-benzyloxycarbonylmethyl-2-(pyrrol-1-yl)malonic acid diethyl ester (80.0 g) in dioxane (150 ml) was hydrogenated over 10% palladium-carbon (500 mg) at 40° C. After the calculated amount of hydrogen was absorbed, the catalyst was filtered off and the filtrate was evaporated under reduced pressure. The residue was recrystallized from ethyl acetate/n-hexane to give the title compound (48.7 g, 80.2%) as colorless crystals, mp 93°-94° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05258382 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-aaf7310e824b4202a08add87a34cb156 |
| 출처 메모 | uspto-grants-1993_11 |