HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → Nilvadipine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 6-Cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid | HCID 15388766 | — |
| Product | Nilvadipine | HCID 4494 | 97.6% |
Reaction Steps
Methyl (-)-5-carboxy-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate (4.47 g) is reacted with phosphorus pentachloride (3.62 g) and isopropyl alcohol (2.5 g) in the same manner as in Example 7 to provide 5-isopropyl 3-methyl (-)-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (4.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05258393 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-e90cb37427224c40bfdf5480d8f2d9c9 |
| Source note | uspto-grants-1993_11 |