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HRID256602

反应详情

EQUATION

反应方程式

HRID 256602 的结构方程式

REACTANTS

反应物

3
结构：CC(C)O
HCID3776

Isopropanol

C3H8O

结构：ClP(Cl)(Cl)(Cl)Cl
HCID24819

Phosphorus pentachloride

Cl5P

结构：COC(=O)C1=C(C#N)NC(C)=C(C(=O)O)C1c1cccc([N+](=O)[O-])c1
HCID15388766

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1
HCID4494

Nilvadipine

C19H19N3O6

收率 97.6%

PROCEDURE

实验过程

Methyl (-)-5-carboxy-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate (4.47 g) is reacted with phosphorus pentachloride (3.62 g) and isopropyl alcohol (2.5 g) in the same manner as in Example 7 to provide 5-isopropyl 3-methyl (-)-2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (4.9 g).