反应详情

A mixture of 3 g of 2,4-dihydroxy-3-propylacetophenone, 2.5 g of ethyl bromoacetate, 2.3 g of anhydrous potassium carbonate, and 30 ml of methyl ethyl ketone was refluxed for 5 hours. Then, the solvent was removed under reduced pressure and after addition of 50 ml of toluene, the mixture was washed with water, a diluted aqueous solution of sodium hydroxide, and water successively, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue thus formed was recrystallized from a mixture of toluene and n-hexane to provide 2.8 g of ethyl (4-acetyl-3-hydroxy-2-propylphenoxy)acetate (melting point: 66° to 66.5° C.).

1. temperaturewas refluxed for 5 hours
2. customThen, the solvent was removed under reduced pressure
3. additionafter addition of 50 ml of toluene
4. washthe mixture was washed with water
5. dry with materiala diluted aqueous solution of sodium hydroxide, and water successively, dried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue thus formed
8. customwas recrystallized from a mixture of toluene and n-hexane