Hydrochloric Acid → HCID 178464213, compound

HRID 25663Notes

Reaction equation

HRID 25663 reaction equation
C(O[C:6](=O)[N:7]([C@H:9]1[CH2:14][CH2:13][C@H:12]([CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:25])[N:20]([CH2:23][CH3:24])[CH2:21][CH3:22])[CH2:11][CH2:10]1)C)(C)(C)C.[ClH:27]>O1CCOCC1.CCOCC>[ClH:27].[CH2:23]([N:20]([CH2:21][CH3:22])[C:19](=[O:25])[CH2:18][CH2:17][CH2:16][CH2:15][C@H:12]1[CH2:11][CH2:10][C@H:9]([NH:7][CH3:6])[CH2:14][CH2:13]1)[CH3:24]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178464214HCID 178464214, compound

Product 1

HCID 178464213HCID 178464213, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent2×

Procedure

To 0.99 g (2.7 mmol) trans-[4-(4-Diethylcarbamoyl-butyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester in 5 ml dioxane were added 7 ml 4M HCl in dioxane at 0° C. The solution was stirred at RT for 2 h, diluted with ether, and the precipitated solid was isolated. 0.83 g (quant.) trans-5-(4-Methylamino-cyclohexyl)-pentanoic acid diethylamide.hydrochloride were isolated as white solid, mp. 122° C., MS: 269 (MH+).

Workup

  1. customthe precipitated solid was isolated

Sources & evidence

ORD record
ord-1f2a6879ce3540d882191229d4f4b02b
Source dataset
uspto-grants-2005_02
Patent number
US06858651B2

Reaction notes

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