Triethylamine → HCID 22309553, compound

HRID 256633Notes

Reaction equation

HRID 256633 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][NH2:8].[Cl:9][C:10]1[C:15]([NH2:16])=[C:14](Cl)[N:13]=[CH:12][N:11]=1.C(N(CC)CC)C>O>[Cl:9][C:10]1[N:11]=[CH:12][N:13]=[C:14]([NH:8][CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:15]=1[NH2:16]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 195092-PyridinemethanamineHCID 794345-Amino-4,6-dichloropyrimidine

Product 1

HCID 22309553HCID 22309553, compoundYield 90.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 3.7 parts of 2-pyridinemethanamine, 4.1 parts of 4,6-dichloropyrimidin-5-amine, 3.03 parts of N,N-diethylethanamine and 150 parts of water was stirred for 8 hours at room temperature. After cooling, the whole was stirred overnight. The product was filtered off, washed with water and dried overnight in vacuo at 80° C., yielding 5.35 parts (90.8%) of 6-chloro-N4 -(2-pyridinylmethyl)-4,5-pyrimidinediamine; mp. 140.3° C. (interm. 1).

Workup

  1. temperatureAfter cooling
  2. stirringthe whole was stirred overnight
  3. filtrationThe product was filtered off
  4. washwashed with water
  5. customdried overnight in vacuo at 80° C.

Sources & evidence

ORD record
ord-8e1ad4289bbd4d9ca76372d7952e4f94
Source dataset
uspto-grants-1993_11
Patent number
US05258380

Reaction notes

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