Hydrogen Bromide → HCID 178419280, compound

HRID 256657Notes

Reaction equation

HRID 256657 reaction equation
Cl[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1)[C:5]([NH:11][CH:12]1[CH2:17][CH2:16][N:15](C(OCC)=O)[CH2:14][CH2:13]1)=[N:6]2.[BrH:31].[OH2:32]>>[BrH:31].[BrH:31].[F:30][C:27]1[CH:28]=[CH:29][C:24]([CH2:23][N:4]2[C:3]3[C:7](=[N:8][CH:9]=[N:10][C:2]=3[OH:32])[N:6]=[C:5]2[NH:11][CH:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)=[CH:25][CH:26]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 19785322ethyl 4-[[6-chloro-7-[(4-fluorophenyl)methyl]-7H-purin-8-yl]amino]-1-piperidinecarboxylate

Product 1

HCID 178419280HCID 178419280, compoundYield 100%

Conditions

Temperature
80 °C

Procedure

A mixture of 7.5 Parts of ethyl 4-[[6-chloro-7-[(4-fluorophenyl)methyl]-7H-purin-8-yl]amino]-1-piperidinecarboxylate and 150 parts of a hydrobromic acid solution 48% in water was stirred overnight at 80° C. The reaction mixture was evaporated. The residue was stirred in 2-propanone. The product was filtered off and dried, yielding 8.5 parts (100%) of 7-[(4-fluorophenyl)methyl]-8-(4-piperidinylamino)-7H-purin-6-ol dihydrobromide as a residue (compound 41).

Workup

  1. customThe reaction mixture was evaporated
  2. stirringThe residue was stirred in 2-propanone
  3. filtrationThe product was filtered off
  4. customdried

Sources & evidence

ORD record
ord-acb4245dea9b4eb4aa0ec96d1c9091a9
Source dataset
uspto-grants-1993_11
Patent number
US05258380

Reaction notes

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