反应详情

A mixture of 3.22 parts of 2-chloroacetonitrile, 16 parts of 9-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-9H-purin-8-amine, 12.7 parts of sodium carbonate and 225 parts of N,N-dimethylformamide was stirred for 6 hours at room temperature. The reaction mixture was poured onto water. The product was extracted twice with trichloromethane. The combined extracts were dried, filtered and evaporated. The residue was crystallized from acetonitrile. The precipitate was filtered off and the filtrate was evaporated, yielding 16 parts of 4-[[9-[(4-fluorophenyl)methyl]-9H-purin-8-yl]amino]-1-piperidineacetonitrile as a residue (compound 147).

1. additionThe reaction mixture was poured onto water
2. extractionThe product was extracted twice with trichloromethane
3. customThe combined extracts were dried
4. filtrationfiltered
5. customevaporated
6. customThe residue was crystallized from acetonitrile
7. filtrationThe precipitate was filtered off
8. customthe filtrate was evaporated