Potassium Hydroxide → HCID 19785336, compound

HRID 256670Notes

Reaction equation

HRID 256670 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]1[C:15]([NH:16][CH:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][NH:25]C(=O)OCC)[CH2:19][CH2:18]2)=[N:14][C:13]2[C:8]1=[N:9][CH:10]=[N:11][CH:12]=2.[OH-].[K+]>CC(O)C>[NH2:25][CH2:24][CH2:23][N:20]1[CH2:19][CH2:18][CH:17]([NH:16][C:15]2[N:7]([CH2:6][C:2]3[S:1][CH:5]=[CH:4][CH:3]=3)[C:8]3[C:13]([N:14]=2)=[CH:12][N:11]=[CH:10][N:9]=3)[CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 86745003HCID 86745003, compound

Product 1

HCID 19785336HCID 19785336, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 10 parts of ethyl [2-[4-[[9-(2-thienylmethyl)-9H-purin-8-yl]amino]-1-piperidinyl]ethyl]carbamate, 10 parts of potassium hydroxide and 240 parts of 2-propanol was stirred overnight at reflux temperature. The reaction mixture was evaporated. Water was added. After stirring, the product was filtered off and dried, yielding 3.6 parts (56%) of N-[1-(2-aminoethyl)-4-piperidinyl]-9-(2-thienylmethyl)-9H-purin-8-amine (compound 163).

Workup

  1. temperatureat reflux temperature
  2. customThe reaction mixture was evaporated
  3. additionWater was added
  4. stirringAfter stirring
  5. filtrationthe product was filtered off
  6. customdried

Sources & evidence

ORD record
ord-6355521d191d4b60a7f809c066a486bf
Source dataset
uspto-grants-1993_11
Patent number
US05258380

Reaction notes

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