反应详情

A solution of sarcosine (30 g, 0.34 mol), methylacrylate (29 g, 0.34 mol) and paraformaldehyde (20.2 g, 0.67 mol) in toluene (3 l) was refluxed in a Dean-Stark trap apparatus for 0.5 h. The reaction mixture was cooled to room temperature and stirred for 16 h. Filtration through cotton wool and concentration under vacuum gave the title ester as a pale yellow liquid (21 g) m/e 143 (M+); δ(250 MHz, CDCl3) 2.05-2.16 (2H, m, CH2); 2.36 (3H, s, N--Me); 2.48-2.84 (4H, m, 2 of CH2 --N); 2.98-3.10 (1H, m, CH--CO2Me); 3.70 (3H, s, CO2Me).

1. filtrationFiltration
2. concentrationthrough cotton wool and concentration under vacuum