p-Toluenesulfonic acid → 4-(3,4-Dihydro-7-methoxynaphth 1-yl)-1-methylpiperidine

HRID 256918Notes

Reaction equation

HRID 256918 reaction equation
O[C:2]1([CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[CH2:5][CH2:4][CH2:3]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>ClCCl>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6]([CH2:5][CH2:4][CH:3]=[C:2]2[CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 197843384-(1-Hydroxy-7-methoxy-1,2,3,4-tetrahydronaphth-1-yl) 1-methylpiperidine

Product 1

HCID 190962484-(3,4-Dihydro-7-methoxynaphth 1-yl)-1-methylpiperidine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 15 g of the oil obtained in Stage A, in 400 ml of anhydrous dichloromethane, is refluxed for 20 minutes in the presence of 11.4 g of para-toluenesulfonic acid.

Sources & evidence

ORD record
ord-979b4bf99f074ecb9d8c7810f02e2c3a
Source dataset
uspto-grants-1993_11
Patent number
US05260317

Reaction notes

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