1-(4-Nitrophenyl)-4-piperidinol → 1-(4-Aminophenyl)piperidin-4-ol

HRID 257080Notes

Reaction equation

HRID 257080 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd].[C]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:11][CH2:12][CH:13]([OH:16])[CH2:14][CH2:15]2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 6137681-(4-Nitrophenyl)-4-piperidinol

Product 1

HCID 167921071-(4-Aminophenyl)piperidin-4-olYield 92.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1.0 g (4.5 mmol) of 1-(4-nitrophenyl)-4-hydroxypiperidine are hydrogenated in a conventional manner with Pd/carbon in methanol. 0.8 g of 1-(4-aminophenyl)-4-hydroxypiperidine is obtained. Melting point 176° C.

Sources & evidence

ORD record
ord-f91963aa89e94024a3450008cf5bfc51
Source dataset
uspto-grants-1993_11
Patent number
US05260318

Reaction notes

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