反应详情

温度

120 °C

A mixture of 2-chlorobenzothiazole (8.5 g) and 2-methylaminoethanol (20 ml) was heated at 120° C. under pressure in a sealed, glass lined, stainless steel reaction vessel for 18 hours. After cooling, the oil was added to water (100 ml), extracted with dichloromethane (2×100 ml), the organic extracts were dried (MgSO4), filtered and evaporated to dryness. Chromatography of the residual oil on silica-gel in 21/2% methanol in dichloromethane gave the title compound which was used in Preparation 1 without further purification.

1. temperatureAfter cooling
2. extractionextracted with dichloromethane (2×100 ml)
3. dry with materialthe organic extracts were dried (MgSO4)
4. filtrationfiltered
5. customevaporated to dryness