Potassium Hydroxide → HCID 14855762, compound

HRID 257198Notes

Reaction equation

HRID 257198 reaction equation
[CH2:1]([C:7]1[N:8]2[C:12](=[C:13]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:14]=1[C:15](=O)[CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH2:11][CH2:10][CH2:9]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH-].[K+].O.NN>C(O)COCCO>[CH2:1]([C:7]1[N:8]2[C:12](=[C:13]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[C:14]=1[CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH2:11][CH2:10][CH2:9]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 14855761HCID 14855761, compound

Product 1

HCID 14855762HCID 14855762, compound

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

1 mmole of 71 is reacted in 10 ml of diethyleneglycol with 50 mmoles (2.8 g) of KOH and 30 mmoles (1.5 g) of hydrazine hydrate similarly to the procedure for reducing the 4-(diphenyl-2,3-dihydro-1H-pyrrolizinyl)-4-oxobutyric acids. Product purification is by means of column chromatography (silica gel/diisopropylether). After concentrating the eluates, 72 remains as an oil.

Workup

  1. customProduct purification
  2. concentrationAfter concentrating the eluates, 72 remains as an oil

Sources & evidence

ORD record
ord-47ba2e7668e642a382fc6a524585a9cd
Source dataset
uspto-grants-1993_11
Patent number
US05260451

Reaction notes

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