反应详情

50.0 g of 4-acetoxy-3-tert-butylbenzoic acid are dissolved in 200 g of methanol. A solution of 10.2 g of sodium hydroxide in 180 ml of water is added. The mixture is refluxed for 3 hours. The methanol is removed, and the mixture is acidified with hydrochloric acid (10%) at 10° C. The precipitate is filtered off and washed, giving 40.6 g of product in the form of colourless crystals having a melting point of from 158° to 159° C.

1. temperatureThe mixture is refluxed for 3 hours
2. customThe methanol is removed
3. customis acidified with hydrochloric acid (10%) at 10° C
4. filtrationThe precipitate is filtered off
5. washwashed