HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-tert-Butyl-4-hydroxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(Acetyloxy)-3-tert-butylbenzoic acid | HCID 18007736 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-tert-Butyl-4-hydroxybenzoic acid | HCID 14401510 | 98.8% |
Reaction Steps
50.0 g of 4-acetoxy-3-tert-butylbenzoic acid are dissolved in 200 g of methanol. A solution of 10.2 g of sodium hydroxide in 180 ml of water is added. The mixture is refluxed for 3 hours. The methanol is removed, and the mixture is acidified with hydrochloric acid (10%) at 10° C. The precipitate is filtered off and washed, giving 40.6 g of product in the form of colourless crystals having a melting point of from 158° to 159° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05261953 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-775757d1a73e4ed2b2ea09f52f98304c |
| Source note | uspto-grants-1993_11 |