3-Fluoro-4-nitrophenol → 4-Amino-3-fluorophenol
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>C(O)(=O)C.O.[Fe]>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([OH:11])=[CH:3][C:2]=1[F:1]Participants
5
Reactant 1
Product 1
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 50 °C
Procedure
To a mixture of 10.0 g (0.0640 mole) of 3-fluoro-4-nitrophenol in 100 mL of acetic acid and 10 mL of water heated to 50° C. was added 10.0 g (0.179 mole) of iron powder in small portions during a 35 minute period. The stirred reaction mixture was heated at 50° C. for an additional three hours, after which it was cooled and filtered. The filtrate was used in Step B without further purification.
Workup
- customThe stirred reaction mixture
- temperaturewas heated at 50° C. for an additional three hours
- temperatureafter which it was cooled
- filtrationfiltered
- customThe filtrate was used in Step B without further purification
Sources & evidence
- ORD record
- ord-4e5a4502abd041cf80b77d4d58cb3666
- Source dataset
- uspto-grants-1993_11
- Patent number
- US05262390
Reaction notes
Loading…