反应详情

To a solution of 13.75 g (0.0967 mole) of 2-fluoro-4-methoxyaniline in 120 mL of toluene was slowly added over a period of 30 minutes a solution of 19.13 g (0.0967 mole) of trichloromethyl chloroformate in 30 mL of toluene. During the addition the temperature rose to 35° C. The reaction mixture was stirred without external heating for 30 minutes and then heated at reflux for approximately 17 hours. At the end of this time all of the solvent was removed by distillation, leaving 2-fluoro-4-methoxyphenyl isocyanate as a purple liquid, which was used immediately in Step D.

1. additionDuring the addition the temperature
2. customrose to 35° C
3. temperaturewithout external heating for 30 minutes
4. temperatureheated
5. temperatureat reflux for approximately 17 hours
6. customAt the end of this time all of the solvent was removed by distillation