反应详情

A mixture of 2.19 g (0.0104 mole) of methyl 2-(4-hydroxymethylphenoxy)propionate and 3.00 g (0.0823 mole) of 36% hydrochloric acid was stirred for fifteen minutes at room temperature. The reaction mixture was then poured into ice-water, and the resulting mixture was extracted with diethyl ether. The extracts were combined and washed in succession with water and a saturated aqueous solution of sodium bicarbonate. The extract was dried over anhydrous magnesium sulfate and filtered, and the solvent was evaporated from the filtrate under reduced pressure, leaving a colorless liquid. This liquid was placed on a column of silica gel and eluted with methylene chloride. After the product-containing fractions were combined and the solvent evaporated under reduced pressure, 1.6 g of methyl 2-(4-chloromethylphenoxy)propionate was isolated as a colorless liquid. The NMR and IR spectra were consistent with the proposed structure.

1. extractionthe resulting mixture was extracted with diethyl ether
2. washwashed in succession with water
3. dry with materialThe extract was dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customthe solvent was evaporated from the filtrate under reduced pressure
6. customleaving a colorless liquid
7. washeluted with methylene chloride
8. customthe solvent evaporated under reduced pressure