Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 4-Chloro-3-nitropyridine | HCID 2735781 | — |
| Product | 4-Amino-3-nitropyridine | HCID 548803 | 59% |
Reaction Steps
Five grams (31.5 mmol) of 3-nitro-4-chloropyridine was mixed with 26 g of ammonium acetate, and the mixture was heated at 130-140° C. for 3 hours. The mixture was allowed to cool, and then adjusted to pH 10 with concentrated aqueous ammonia. The precipitated powder was collected by filtration to obtain 2.6 g of the intended yield: 59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05262415 |
|---|
| Source dataset | uspto-grants-1993_11 |
|---|
| ORD ID | ord-346aaf12786f4e2591f295f5d73eca29 |
|---|
| Source note | uspto-grants-1993_11 |
|---|
