Hydrochloric Acid → HCID 14838241, compound

HRID 257433Notes

Reaction equation

HRID 257433 reaction equation
C([NH:4][C:5]1[C:10]2[CH2:11][C:12]([CH3:15])([CH3:14])[O:13][C:9]=2[C:8]([C:16]([O:18]C)=[O:17])=[CH:7][CH:6]=1)(=O)C.[OH-].[K+].Cl>O>[NH2:4][C:5]1[C:10]2[CH2:11][C:12]([CH3:15])([CH3:14])[O:13][C:9]=2[C:8]([C:16]([OH:18])=[O:17])=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 10682963HCID 10682963, compound

Product 1

HCID 14838241HCID 14838241, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 58 parts of methyl 4-(acetylamino)-2,3-dihydro-2,2-dimethyl-7-benzofurancarboxylate, 123 parts of potassium hydroxide and 1100 parts of water was stirred for 3 hours at reflux temperature. After cooling, the reaction mixture was acidified to pH 1 with HCl. The precipitate was filtered off and dried in vacuo at 80° C., yielding 36 parts (79.0%) of 4-amino-2,3-dihydro-2,2-dimethyl-7-benzofurancarboxylic acid (interm. 6).

Workup

  1. temperatureat reflux temperature
  2. temperatureAfter cooling
  3. filtrationThe precipitate was filtered off
  4. customdried in vacuo at 80° C.

Sources & evidence

ORD record
ord-15c9f1dc70bf4908929b5ce1d2d94330
Source dataset
uspto-grants-1993_11
Patent number
US05262418

Reaction notes

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