Hydrazine hydrate (1:1) → HCID 780187, compound

HRID 257456Notes

Reaction equation

HRID 257456 reaction equation
O.[NH2:2][NH2:3].[Cl:4][C:5]1[CH:21]=[CH:20][C:8]([CH2:9][O:10][C:11]2[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1>C(O)C>[Cl:4][C:5]1[CH:21]=[CH:20][C:8]([CH2:9][O:10][C:11]2[CH:19]=[CH:18][C:14]([C:15]([NH:2][NH2:3])=[O:16])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 9616084-[(4-chlorobenzyl)oxy]benzoic acid

Product 1

HCID 780187HCID 780187, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.75 mol of hydrazine hydrate was added to a solution of 0.275 mol of ethyl ester of 4-(4-chloro benzyloxy) benzoic acid (X) in 300 ml ethanol. The reaction medium was reflux-heated for 48 hours. After cooling, the expected product was separated by filtration and recrystallised from ethanol.

Workup

  1. temperatureThe reaction medium was reflux-heated for 48 hours
  2. temperatureAfter cooling
  3. customthe expected product was separated by filtration
  4. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-ba57656cba7245db8ee70cdb58b2afc5
Source dataset
uspto-grants-1993_11
Patent number
US05262432

Reaction notes

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