3-Ethyl-4-methylpyridine → 1-(3,4-Dichlorophenyl)-4-(3-ethyl-4-pyridyl)-butane

HRID 257489Notes

Reaction equation

HRID 257489 reaction equation
[CH2:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[CH3:9])[CH3:2].Br[CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1>>[Cl:21][C:16]1[CH:15]=[C:14]([CH2:13][CH2:12][CH2:11][CH2:9][C:8]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[CH2:1][CH3:2])[CH:19]=[CH:18][C:17]=1[Cl:20]

Participants

3

Reactant 2

HCID 682543-Ethyl-4-methylpyridineHCID 219629574-(3-bromopropyl)-1,2-dichloroBenzene

Product 1

HCID 148837971-(3,4-Dichlorophenyl)-4-(3-ethyl-4-pyridyl)-butaneYield 46.9%

Procedure

1.83 g (15.1 mmol) of 3-ethyl-4-methypyridine and 4.05 g (15.1 mmol) of 1-bromo-3-(3,4-dichlorophenyl)-propane were reacted in the same manner as in Example 26. The reaction product was purified to obtain 2.18 g of the desired compound (yield: 46.9%). The resulting compound was identified as 1-(3,4-dichlorophenyl)-4-(3-ethyl-4-pyridyl)-butane (hereinafter referred to as compound 51) by the following analytical results.

Workup

  1. customThe reaction product was purified

Sources & evidence

ORD record
ord-7066780fb54943e7af17fba3eed20548
Source dataset
uspto-grants-1993_11
Patent number
US05262420

Reaction notes

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