Ethylene Glycol → HCID 54120303, compound

HRID 257496Notes

Reaction equation

HRID 257496 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:10]([CH2:11][C:12]([OH:14])=[O:13])[N:9]=[N:8][N:7]=2)=[CH:2]1.S(=O)(=O)(O)O.[CH2:20](O)[CH2:21][OH:22]>>[OH:22][CH2:21][CH2:20][O:13][C:12](=[O:14])[CH2:11][N:10]1[C:6]([C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)=[N:7][N:8]=[N:9]1

Participants

4

Reactant 3

HCID 174Ethylene GlycolHCID 1118Sulfuric AcidHCID 3035658(5-(3-Thienyl)tetrazol-1-yl)acetic acid

Product 1

HCID 54120303HCID 54120303, compoundYield 50%

Conditions

Temperature
90 °C

Procedure

To a solution of 1 g (4.7 mM) of [5-(3-thienyl)tetrazol-1-yl] acetic acid in 5 ml of ethylene glycol was added 0.5 ml of sulfuric acid. After the addition, the mixture was stirred at 90° C. for 2.5 hrs. The mixture was then poured into ice-water and the precipitated crystal was filtered off, washed with water and recrystrallized from ethyl alcohol, to give 620 mg (yield 50%) of [5-(3-thienyl)tetrazol-1-yl] acetic acid 2-hydroxyethyl ester.

Workup

  1. additionAfter the addition
  2. filtrationthe precipitated crystal was filtered off
  3. washwashed with water

Sources & evidence

ORD record
ord-2b86e4e8f877413c8afcc4273d569e4a
Source dataset
uspto-grants-1993_11
Patent number
US05262433

Reaction notes

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