Ethyl 3-Hydrazino-4-(trifluoromethyl)benzoate hydrochloride → 3-n-Butyl-1-[5-(ethoxycarbonyl)-2-(trifluoromethyl)phenyl]-4-[(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl]-1H-pyrazole-5-carbonitrile

HRID 257581Notes

Reaction equation

HRID 257581 reaction equation
C([NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([C:29](=O)[CH2:30][CH2:31][CH2:32][CH3:33])[C:23](=NOC)[C:24]#[N:25])=[C:17]([F:35])[CH:16]=1)(=[O:8])=[O:7])(C)(C)C.Cl.[NH:37]([C:39]1[CH:40]=[C:41]([CH:47]=[CH:48][C:49]=1[C:50]([F:53])([F:52])[F:51])[C:42]([O:44][CH2:45][CH3:46])=[O:43])[NH2:38]>>[CH2:30]([C:29]1[C:22]([CH2:21][C:18]2[CH:19]=[CH:20][C:15]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[S:6](=[O:8])(=[O:7])[NH2:5])=[CH:16][C:17]=2[F:35])=[C:23]([C:24]#[N:25])[N:37]([C:39]2[CH:40]=[C:41]([C:42]([O:44][CH2:45][CH3:46])=[O:43])[CH:47]=[CH:48][C:49]=2[C:50]([F:51])([F:52])[F:53])[N:38]=1)[CH2:31][CH2:32][CH3:33]

Participants

3

Reactant 2

HCID 19783209Ethyl 3-Hydrazino-4-(trifluoromethyl)benzoate hydrochlorideHCID 541817223-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-methoxyimino-4-oxooctanenitrile

Product 1

HCID 197831793-n-Butyl-1-[5-(ethoxycarbonyl)-2-(trifluoromethyl)phenyl]-4-[(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl]-1H-pyrazole-5-carbonitrile

Procedure

The title compound is prepared by reaction of 3-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2-methoxyimino-4-oxooctanenitrile (from Step J) with ethyl 3-hydrazino-4-(trifluoromethyl)benzoate hydrochloride (from Step E) according to the procedure of Example 1, Step G.

Sources & evidence

ORD record
ord-b9c2907333554f4db901efcabb4d0788
Source dataset
uspto-grants-1993_11
Patent number
US05262412

Reaction notes

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