HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 5-(1-((Tert-butoxy)carbonyl)piperidin-4-yl)pentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 5-(4-piperidyl)pentanoate | HCID 19781432 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Potassium bisulfate | HCID 516920 | — |
| Product | 5-(1-((Tert-butoxy)carbonyl)piperidin-4-yl)pentanoic acid | HCID 10731873 | — |
Reaction Steps
A mixture of ester 15 (200 mg, 0.7 mmol), in NaOH (1.0 mL, 1.0 mmol), and CH3OH (4.0 mL) was stirred at ambient temperature for 20 hours. The reaction mixture was then diluted sequentially with 5% KHSO4 and ethyl acetate. The ethyl acetate portion was washed with brine, dried (MgSO4), and concentrated to give the carboxylic acid 16 (190 mg) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05264420 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-b328f86e23db40c196eb691a4832c806 |
| Source note | uspto-grants-1993_11 |