反应详情

A mixture of ester 15 (200 mg, 0.7 mmol), in NaOH (1.0 mL, 1.0 mmol), and CH3OH (4.0 mL) was stirred at ambient temperature for 20 hours. The reaction mixture was then diluted sequentially with 5% KHSO4 and ethyl acetate. The ethyl acetate portion was washed with brine, dried (MgSO4), and concentrated to give the carboxylic acid 16 (190 mg) as a colorless oil.

1. washThe ethyl acetate portion was washed with brine
2. dry with materialdried (MgSO4)
3. concentrationconcentrated