Methanol → 5-(1-((Tert-butoxy)carbonyl)piperidin-4-yl)pentanoic acid

HRID 257739ノート

反応式

HRID 257739 の反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]C)=[O:12])[CH2:3][CH2:2]1.[OH-:15].[Na+].[CH3:17][OH:18]>OS([O-])(=O)=O.[K+].C(OCC)(=O)C>[C:17]([N:1]1[CH2:2][CH2:3][CH:4]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:5][CH2:6]1)([O:18][C:4]([CH3:7])([CH3:5])[CH3:3])=[O:15]

参加物

6

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 19781432Methyl 5-(4-piperidyl)pentanoate

生成物 1

HCID 107318735-(1-((Tert-butoxy)carbonyl)piperidin-4-yl)pentanoic acid

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 516920Potassium bisulfate溶媒

実験手順

A mixture of ester 15 (200 mg, 0.7 mmol), in NaOH (1.0 mL, 1.0 mmol), and CH3OH (4.0 mL) was stirred at ambient temperature for 20 hours. The reaction mixture was then diluted sequentially with 5% KHSO4 and ethyl acetate. The ethyl acetate portion was washed with brine, dried (MgSO4), and concentrated to give the carboxylic acid 16 (190 mg) as a colorless oil.

後処理

  1. washThe ethyl acetate portion was washed with brine
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-b328f86e23db40c196eb691a4832c806
出典データセット
uspto-grants-1993_11
特許番号
US05264420

反応ノート

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