Maleic Acid → HCID 67760077, compound

HRID 257752Notes

Reaction equation

HRID 257752 reaction equation
[CH:1]([NH:4][C:5]1[N:10]=[C:9]([CH3:11])[C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][N:6]=1)([CH3:3])[CH3:2].[C:16]([OH:23])(=[O:22])/[CH:17]=[CH:18]\[C:19]([OH:21])=[O:20]>C(O)C.C(Cl)(Cl)Cl>[C:16]([OH:23])(=[O:22])/[CH:17]=[CH:18]\[C:19]([OH:21])=[O:20].[CH:1]([NH:4][C:5]1[N:10]=[C:9]([CH3:11])[C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][N:6]=1)([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 444266Maleic AcidHCID 19781542HCID 19781542, compound

Product 1

HCID 67760077HCID 67760077, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6212ChloroformSolvent

Procedure

2.48 g (11.9 g mmoles) of 2-isopropylamino-4-methyl-5-methoxycarbonylpyrimidine and 1.38 g (11.9 mmoles) of maleic acid were dissolved in a mixture of 20 ml of ethanol and 20 ml of chloroform, and the solution was stirred for 3 hours. The solvents were evaporated, and ether was added for crystallization at 0° C. The desired product was obtained in an amount of 3.21 g (yield 83%) as pale yellow crystals.

Workup

  1. customThe solvents were evaporated
  2. additionether was added for crystallization at 0° C

Sources & evidence

ORD record
ord-003aba906cf0405bb1125ae42746e2e3
Source dataset
uspto-grants-1993_11
Patent number
US05264435

Reaction notes

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