反应详情

A mixture of methyl 4-chloromethyl-2-nitrobenzoate (1.6 g), 28% sodium methoxide-methanol solution (2.5 ml) in methanol [16 ml) was stirred under reflux for 24 hours. To this mixture, water (5 ml) was added and the mixture was stirred for 2 hours, acidified with 1N hydrochloric acid, extracted with ethyl acetate. The combined organic extract was washed with water, dried over magnesium sulfate and evaporated to give 4-methoxymethyl-2-nitrobenzoic acid (0.84 g).

1. temperatureunder reflux for 24 hours
2. stirringthe mixture was stirred for 2 hours
3. extractionextracted with ethyl acetate
4. extractionThe combined organic extract
5. washwas washed with water
6. dry with materialdried over magnesium sulfate
7. customevaporated