Hydrochloric Acid → HCID 19092322, compound

HRID 257776Notes

Reaction equation

[C:1]1([C:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]3[C:26](=[O:27])[C:25]4[C:20](=[CH:21][CH:22]=[C:23]([NH:28][S:29]([CH3:32])(=[O:31])=[O:30])[CH:24]=4)[NH:19][C:18]3=[O:33])[CH2:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:34]>CO>[ClH:34].[C:1]1([C:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]3[C:26](=[O:27])[C:25]4[C:20](=[CH:21][CH:22]=[C:23]([NH:28][S:29]([CH3:32])(=[O:31])=[O:30])[CH:24]=4)[NH:19][C:18]3=[O:33])[CH2:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Conditions

Temperature: 5 °C

Procedure

To a stirred solution of 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-6-methylsulfonylamino-1,2,3,4-tetrahydroquinazoline-2,4-dione (158 mg) in methanol was added 10% hydrogen chloride in methanol solution (123 mg) at 5° C. After stirring for 1 hour at 5° C., the solution was evaporated. The residue was crystallized from isopropyl alcohol-ethyl acetate to give 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-6-methylsulfonylamino-1,2,3,4-tetrahydroquinazoline-2,4-dione hydrochloride [81 mg).

Workup

customthe solution was evaporated
customThe residue was crystallized from isopropyl alcohol-ethyl acetate

Sources & evidence

ORD record: ord-2996e30079364d6ea8b9dc0ac26dc50a
Source dataset: uspto-grants-1993_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05264438

Reaction notes

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