HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 2-[4-(aminomethyl)phenoxy]-2-(2-chlorophenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | HCID 19781831 | HCID 19781831 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 2-[4-(aminomethyl)phenoxy]-2-(2-chlorophenyl)acetate | HCID 19781920 | — |
Reaction Steps
A solution of the product of Step E in dry tetrahydrofuran is treated protionwise with triphenylphosphine (1 equivalent). The solution is stirred under N2 at ambient temperature. After about 2 hours, when gas evolution has ceased, H2O (1 equivalent) is added, and the solution is concentrated in vacuo, and the residue is chromatographed on silica gel to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05264439 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-97fa05373712477db9538988520d44fc |
| Source note | uspto-grants-1993_11 |